The About Me and the My Interests sections seem a bit redundant. Generally, you don't need both. I feel like you could just keep the About Me part and cut out the My Interests as people usually put their interests in their About Me anyway.
And the huge white space under the Buddies section is a huge waste of page space. If you can move the signature/local time bubble up under the My Buddies section, it should take up that extra space pretty well and then the comments section can get moved up so there;s not a huge white space.
And if it's possible, perhaps making the comments collapsible. It would help reduce the page size, but still be accessible to people who want to read them.